Note: to avoid spoilers, we will not be detailing or showing footage from the True Ending for Resident Evil 2 until the game has been out for a little while, hence why this guide is pretty dang short.
Resident Evil 2 is a pretty robust game in terms of content. Playing through the A scenarios for both characters depends on how many safe havens you find yourself in as you anxiously wait for the mayhem outside to cool down and how comprehensively you explore everywhere, but you can expect anywhere from 5-10 hours to beat either. Once you’re done with those, you can then move on to completing the B scenarios (also known as 2nd Runs), which remixes the experience for both characters.
This entails the other main character in a respective scenario having their timeline playable. This is difficult to explain simply, but here goes: when playing as Leon, Claire will approach him at the fence of the Police Station just after the helicopter crashes. After beating your 1st Run with Claire, you will then unlock the ability to play a 2nd Run as her, which will fill in the gaps before and after Claire approaches Leon at the fence for what is a mostly different experience.
To unlock the True Ending for Resident Evil 2, you simply need to complete the 2nd Run for either (not both) of the main characters. There will be some small differences in the True Endings depending on who you play as, but they remain largely the same. A trophy/achievement will also be rewarded for unlocking a True Ending in Resident Evil 2.
“Resident Evil 2 is, quite simply, one of the best remakes of all-time. Capcom have nailed their new vision of a classic just like they did back in 2002 by modernising a decades old game to feel like something completely fresh. Whether you want to take a trip down memory lane or are just experiencing the disconcerting decadence of the police station for the first time, Resident Evil 2 is the first essential purchase of 2019.”